Federer, who has won 32 consecutive sets at the tournament and held serve 81 games in a row, was asked whether he paused for even a moment to wonder why he wasn't being given more of a test.
Kiki Bertens followed up her win over Venus Williams by beating No. 7 Karolina Pliskova, 6-3, 7-6 (7-2), to reach the quarterfinals for the first time.
Roger Federer cruised into yet another Wimbledon quarter-final with one of the most straightforward wins of his career on Monday.
Like Federer, Nadal has yet to drop a set here on reaching the quarter-finals for the first time since 2011 - since when his record at the All England Club has been mediocre.
Federer lost a mere five points in the 16-minute opening set against Mannarino on Centre Court and saved his first break point of this year's Championships with an ace.
"It was tougher than the scoreline, " Williams said.
"I've often said the day that you don't feel nervous is the day you should be more anxious about".
Federer said: "I told my team the other day that for me also, after all these years, it is surprising to be the No 1 seed, in the top two in the rankings at 36". Depends against who you play you have less or more chances to win.
Those are all 30-plus and battle-hardened - as are Gilles Simon and the world No 1, Nadal. His problem has always been the first week of Wimbledon, not the second week.
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In other photos , Gadot cradles a very young girl who is being treated at the hospital, as well as meeting more staffers. The sequel to the 2017 smash hit Wonder Woman is one of the most anticipated superhero movies coming out next year.
World number one Nadal, the two-time champion, reached his first quarterfinal at Wimbledon since 2011 - when he went on to finish runner-up - with a 6-3, 6-3, 6-4 win over Jiri Vesely of the Czech Republic.
BBC reports that the top seed is bidding for a joint record ninth singles title to draw level with Martina Navratilova.
Bertens, who was contemplating retirement a year ago after losing her enthusiasm for the sport, is the first Dutch woman to reach the Wimbledon quarterfinals since Michaella Krajicek in 2007.
The big Argentine was looking to set up a mouth-watering quarter-final against Rafael Nadal, looking to avenge his defeat by the Spaniard, seeded second at Wimbledon, in the French Open semi-finals last month.
Federer was first on Centre Court on Monday for what is known as Wimbledon's "Manic Monday", in which all 32 remaining singles players vie for a place in the quarterfinals.
On Wednesday he will need to break new ground again if he is to keep alive his Wimbledon dream and beat eight-times champion Roger Federer for the first time.
Nadal hit 37 winners to only 12 unforced errors and erased the only break he allowed by breaking back immediately in the third set.
"It's true that opponents probably played some good matches, but what happened is that I was not playing the right way". "After she was complaining, they were talking in Chinese, whatever language". "But when I come here, I come here thinking that I can do a good result, no?" Kerber, who won the Australian and U.S. Open titles in 2016, is seeded 11th - making her the highest ranked woman left in the draw.
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