Coronavirus vaccine in first human trial shows signs of creating immunity

Dr. Rhonda Flores labels protein samples at Novavax labs in Gaithersburg Maryland United States

A vaccine manufacturer is reporting preliminary data suggesting its COVID-19 vaccine is safe, and appears to be eliciting in test subjects the kind of immune response capable of preventing disease.

The Moderna vaccine is made using messenger RNA, or mRNA, a molecule containing the genetic instructions to make a protein on the coronavirus surface that is recognized by our immune systems.

Even as CureVac's vaccine moves into clinical trials, Wall Street analysts will likely show interest in its preclinical results-and how they compare to those reported by Moderna, which saw its stock skyrocket 23% on Monday on news of positive data from a mouse trial and small human study of its COVID-19 vaccine candidate, mRNA-1273.

"They were able to demonstrate that some of these antibodies are extremely potent in their ability to block the virus from being able infect human cells".

Moderna also said that the trial produced neutralizing antibodies, which seem to be important in acquiring protection, in at least 8 participants.

Moderna said during its Phase 2 trial will focus on two dosage levels. The next phase will test doses between 25 and 100 micrograms.

Phase 2 COVID-19 reopening takes effect Tuesday
She says each business must have a COVID-19 safety plan in place that customers, employees and public health officials may access. There are 355 active cases of COVID-19 in the province, and 1,932 people who tested positive for COVID-19 have recovered.

People in the highest dose group received only one inoculation. The only side effect was in one patient where there was redness around the injection site. "Data on a second dose was not available for the 250 microgram group, the company said".

"By about the end of the year, the start of next year, there's a reasonable likelihood that we'll see this vaccine on the market, at least on the American market", he said in the Channel 12 interview from Moderna's headquarters in MA. People who received two doses at 100 microgram had binding antibody levels that "significantly exceeded" the levels seen in the blood of Covid-19 survivors.

In the Moderna study, three participants developed fever and other flu-like symptoms when they received the vaccine at a dose of 250 micrograms. Researchers said the vaccine showed evidence it could prevent the virus from replicating in the body. Zaks said he agreed with that estimate for Moderna's vaccine, putting a delivery date somewhere between January and June of next year.

Even as parts of the U.S. begin to reopen, expert continue to warn that we really won't be free of coronavirus until there is a vaccine against it. According to Moderna, there are encouraging early signs that the shot generates antibodies against the COVID-19 virus, SARS-CoV-2, in levels that were similar to or higher than those seen in the plasma of people who recovered from infections.

Countries and private companies around the world are in a race to create a working vaccine, and the aiming to have hundreds of millions of doses of a vaccine broadly available by the end of the year. That worry has led some to propose conducting human challenge trials.

It also remains unclear how long immunity will last from a vaccine when it comes to this virus - and whether mutations will require annual vaccinations as is the case with influenza.

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