US announces clinical trial of antibody treatment for COVID-19

Eli Lilly tests antibody drug to halt COVID-19 spread in U.S. nursing homes

The National Institute of Health (NIH), along with its National Institute of Allergy and Infectious Diseases arm, will conduct a Phase 2 clinical trial of Eli Lilly's (LLY) LY-CoV555 monoclonal antibody.

To address the challenging aspects of running a clinical trial in a long-term care facility during a pandemic, Lilly created customized mobile research units to support the on-site study.

The studies will also receive support through Operation Warp Speed, the White House initiative aimed at accelerating access to vaccines and treatments to fight COVID-19.

Participants will be given one dose of LY-CoV555, and will be monitored while researchers determine its ability to reduce infection rates and treat those who have already been infected with the virus.

Daniel said that clinical trials are not easy in the current environment. "We're working as fast as we can to create medicines that might stop the spread of the virus to these vulnerable individuals". Even after this, we are taking this challenge so that the needy people can be helped.

"COVID-19 has had a devastating impact on nursing home residents", he said.

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The medicine is an antibody against the new coronavirus called LY-CoV555, which was identified in the blood sample of a recovered patient by Canada's Abcellera Biologics. Over the following weeks, Regeneron Pharmaceuticals moved a rival candidate into the clinic and AstraZeneca outlined plans to start testing its COVID-19 antibody asset in humans by August.

To run the study, Lilly is using customized recreational vehicles to take the antibody and personnel to USA nursing homes where a resident or staff member has been infected. Lilly scientists rapidly developed the antibody in less than three months after it was discovered by AbCellera and tested by the scientists at the NIAID Vaccine Research Center.

If successful, the trial will transition to a phase III study and enroll an additional 1,780 outpatient volunteers.

LY-CoV555 has been well tolerated at all doses tested and no drug-related severe adverse events (SAEs) have been observed to date.

Lilly is committed to the rapid release of important scientific data. The company said its drug may get government approval by the end of 2020.

Coronavirus therapeutic development news is published by Precision Vaccinations.

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