Moderna's COVID-19 Vaccine Found 94.5% Effective | IE

Person getting vaccine

Moderna says that within the coming weeks it will be submitting for an Emergency Use Authorization of its vaccine candidate based on the results, looking to get approval from the FDA to use it in emergency circumstances ahead of a full and final approval.

USA biotech company Moderna on Monday announced a potential Covid-19 vaccine, which has been shown to be 94.5 per cent effective at protecting people from coronavirus, according to interim results from late-stage clinical trials. US health officials have said that at first they are most likely to distribute vaccines to healthcare workers, people who are in nursing homes, first responders and those with health conditions who are high-risk. Leading up to the final analysis, Moderna expects the point estimate for vaccine efficacy may change.

The preliminary data is based on an evaluation of 95 confirmed Covid-19 infections among the trial's 30,000 participants.

Pfizer's vaccine, on the other hand, needs to be stored in deep-freezer conditions which could complicate supply chain logistics, particularly in less developed countries.

The US drugmaker said it was informed by the Data Safety Monitoring Board that its vaccine, mRNA-1273, has met the statistical criteria required for the study.

The start of further clinical trials in the UK is yet another step forward in the race to discover a safe and effective vaccine, and comes alongside recent news that we could be on the cusp of the first major breakthrough since the pandemic began, said UK Business Secretary Alok Sharma. 6,000 British volunteers have signed up to participate in the Phase-3 trial. It marks the third potential vaccine to enter clinical trials in the United Kingdom, alongside U.S. biotech company Novavax and University of Oxford/ AstraZeneca, whose studies remain ongoing.

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Shares in Moderna rose 9% in pre-market trading on Monday after an independent health board said its COVID-19 vaccine is nearly 95% effective.

mRNA-1273 is a novel lipid nanoparticle (LNP)-encapsulated mRNA vaccine encoding for a prefusion stabilized form of the Spike (S) protein. mRNA-1273 is one of 20 "Front Runner" candidates among the more than 300 COVID-19 therapeutics included in GEN's updated "COVID-19 Drug & Vaccine Candidate Tracker".

All the vaccines that are being trialled work by generating immune responses to the same part of the coronavirus as the RNA vaccine that has announced some interim early results, he said.

These adverse events were "short lived", according to a statement.

Moderna is conducting the COVE trial with the NIH's National Institute of Allergy and Infectious Diseases (NIAID) and the Biomedical Advanced Research and Development Authority (BARDA).

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