Early trials show promise for Sinovac vaccine, East Asia News & Top Stories

Early results indicate AstraZeneca/Oxford vaccine is promising

Pollard discussed progress in the late-stage trials as Oxford released a study based on earlier research that found the vaccine was well tolerated and produced a strong immune response in people over 70.

The researchers also stress that 240 participants were over the age of 70 and their immune responses were similar to younger people in this clinical trial as well as the results from the younger cohort from Phase I. This is a very important result given how older adults are one of the most-at-risk groups.

Infectious disease specialists answer questions about COVID-19 vaccines including if results from clinical trials will hold up in the real world. "The next step will be to see if this translates into protection from the disease itself", he added.

"As a result, it is crucial that COVID-19 vaccines are tested in this group who are also a priority group for immunization", he said in a news release from the journal The Lancet. The human body can become immune to the adenoviral vectors used in the vaccine, which makes booster shots more hard. T-cell response occurred within 14 days of the first dose of vaccination, and antibody response occurred within 28 days of the booster dose of vaccination. And it turns out that older adults are less likely to have local reactions where they got the injection and symptoms on the day of vaccination compared to younger people.

Vials of the Oxford coronavirus vaccine
Vials of the Oxford coronavirus vaccine

The authors note some limitations to their study, including that the participants in the oldest age group had an average age of 73-74 and few underlying health conditions, so they may not be representative of the general older population, including those living in residential care settings or aged over 80. Oxford and AstraZeneca are waiting for the results of phase III trials on thousands of people around the world to show whether their vaccine is safe and effective. If other vaccines are also authorised, hundreds of millions of doses could be available by the spring, according to federal officials.

Pfizer and BioNTech seek emergency vaccine approva.

Separately, Pfizer's chief executive Albert Bourla said on Tuesday that the firm plans to submit its vaccine data to the US Food and Drug Administration for emergency-use authorisation.

The goal of adenovirus-vectored vaccines is to convince the body that it has been infected so that it will be able to successfully fight real viruses if they enter the body.

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